Consulta: creatorFacets:"Destoumieux-garzón, Delphine"
Registros recuperados: 5
Data/hora: 18/05/2024 10:17:37

Alterins Produced by Oyster-Associated Pseudoalteromonas are Antibacterial Cyclolipopeptides with LPS-Binding Activity
Provedor de dados: Institutional Archive of Ifreme (ArchiMer)
Autores: Desriac, Florie; El Harras, Abderrafek; Simon, Matthieu; Bondon, Arnaud; Brillet, Benjamin; Le Chevalier, Patrick; Pugnière, Martine; Got, Patrice; Destoumieux-garzón, Delphine; Fleury, Yannick.
Discovery after discovery, host-associated microbiota reveal a growing list of positive effects on host homeostasis by contributing to host nutrition, improving hosts’ immune systems and protecting hosts against pathogens. In that context, a collection of oyster associated bacteria producing antibacterial compounds have been established to evaluate their role in non-host-derived immunity. Here, we described alterins; potent anti-Gram negative compounds produced by Pseudoalteromonas hCg-6 and hCg-42 isolated from different healthy oyster hemolymph. The strains hCg-6 and hCg-42 produce a set of at least seven antibacterial compounds, ranging from 926 to 982 Da structurally characterized as cyclolipopeptides (CLPs). Alterins share the same cationic...
Tipo: Text
Palavras-chave: Pseudoalteromonas; Cyclolipopeptides; Alterin; Antibiotic.
Ano: 2020
URL: https://archimer.ifremer.fr/doc/00663/77511/79275.pdf

Animal board invited review: OneARK: Strengthening the links between animal production science and animal ecology
Provedor de dados: Institutional Archive of Ifreme (ArchiMer)
Autores: Destoumieux-garzón, Delphine; Bonnet, P.; Teplitsky, C.; Criscuolo, F.; Henry, P.-y.; Mazurais, David; Prunet, P.; Salvat, Gilles; Usseglio-polatera, P.; Verrier, E.; Friggens, N.c.
Wild and farmed animals are key elements of natural and managed ecosystems that deliver functions such as pollination, pest control and nutrient cycling within the broader roles they play in contributing to biodiversity and to every category of ecosystem services. They are subjected to global changes with a profound impact on the natural range and viability of animal species, the emergence and spatial distribution of pathogens, land use, ecosystem services and farming sustainability. We urgently need to improve our understanding of how animal populations can respond adaptively and therefore sustainably to these new selective pressures. In this context, we explored the common points between animal production science and animal ecology to identify promising...
Tipo: Text
Palavras-chave: Adaptation; Agroecosystem; Livestock sustainability; Resilience; Zoonotic disease.
Ano: 2021
URL: https://archimer.ifremer.fr/doc/00663/77509/79273.pdf

Resistance to Antimicrobial Peptides in Vibrios
Provedor de dados: Institutional Archive of Ifreme (ArchiMer)
Autores: Destoumieux-garzón, Delphine; Duperthuy, Marylise; Vanhove, Audrey; Schmitt, Paulina; Wai, Sun.
Vibrios are associated with a broad diversity of hosts that produce antimicrobial peptides (AMPs) as part of their defense against microbial infections. In particular, vibrios colonize epithelia, which function as protective barriers and express AMPs as a first line of chemical defense against pathogens. Recent studies have shown they can also colonize phagocytes, key components of the animal immune system. Phagocytes infiltrate infected tissues and use AMPs to kill the phagocytosed microorganisms intracellularly, or deliver their antimicrobial content extracellularly to circumvent tissue infection. We review here the mechanisms by which vibrios have evolved the capacity to evade or resist the potent antimicrobial defenses of the immune cells or tissues...
Tipo: Text
Palavras-chave: Vibrio; Lipopolysaccharide; Outer membrane vesicle; Membrane transporter; Innate immunity; Defensin; Cathelicidin; Bactericidal/permeability-increasing protein.
Ano: 2014
URL: http://archimer.ifremer.fr/doc/00276/38767/37308.pdf

The Ancestral N-Terminal Domain of Big Defensins Drives Bacterially Triggered Assembly into Antimicrobial Nanonets
Provedor de dados: Institutional Archive of Ifreme (ArchiMer)
Autores: Loth, Karine; Vergnes, Agnes; Barreto, Cairé; Voisin, Sébastien N; Meudal, Hervé; Da Silva, Jennifer; Bressan, Albert; Belmadi, Nawal; Bachère, Evelyne; Aucagne, Vincent; Cazevielle, Chantal; Marchandin, Hélène; Rosa, Rafael Diego; Bulet, Philippe; Touqui, Lhousseine; Delmas, Agnès F.; Destoumieux-garzón, Delphine.
Big defensins, ancestors of β-defensins, are composed of a β-defensin-like C-terminal domain and a globular hydrophobic ancestral N-terminal domain. This unique structure is found in a limited number of phylogenetically distant species, including mollusks, ancestral chelicerates, and early-branching cephalochordates, mostly living in marine environments. One puzzling evolutionary issue concerns the advantage for these species of having maintained a hydrophobic domain lost during evolution toward β-defensins. Using native ligation chemistry, we produced the oyster Crassostrea gigas BigDef1 (Cg-BigDef1) and its separate domains. Cg-BigDef1 showed salt-stable and broad-range bactericidal activity, including against multidrug-resistant human clinical isolates...
Tipo: Text
Palavras-chave: MRSA; Antimicrobial peptides; Antimicrobial resistance; Defensins; Fibrils; Innate immunity; Mechanisms of action; Nuclear magnetic resonance.
Ano: 2019
URL: https://archimer.ifremer.fr/doc/00588/70057/68000.pdf

Vibrio splendidus   O-antigen structure: A trade-off between virulence to oysters and resistance to grazers
Provedor de dados: Institutional Archive of Ifreme (ArchiMer)
Autores: Oyanedel, Daniel; Labreuche, Yannick; Bruto, Maxime; Amraoui, Hajar; Robino, Etienne; Haffner, Philippe; Rubio, Tristan; Charrière, Guillaume; Le Roux, Frederique; Destoumieux-garzón, Delphine.
A major debate in evolutionary biology is whether virulence is maintained as an adaptive trait and/or evolves to non‐virulence. In the environment, virulence traits of non‐obligatory parasites are subjected to diverse selective pressures and trade‐offs. Here we focus on a population of Vibrio splendidus that displays moderate virulence for oysters. A MARTX (Multifunctional‐autoprocessing repeats‐in‐toxin) and a type‐six secretion system (T6SS) were found to be necessary for virulence toward oysters, while a region (wbe) involved in O‐antigen synthesis is necessary for resistance to predation against amoebae. Gene inactivation within the wbe region had major consequences on the O‐antigen structure, conferring lower immunogenicity, competitive advantage and...
Tipo: Text
Ano: 2020
URL: https://archimer.ifremer.fr/doc/00619/73070/72194.pdf